our latest manuscripts

Clinical Trials

Clinical trials evaluating the effects of glucan in children with respiratory problems bring glucan closer to being approved as a drug. Studies performed in our laboratory showed significant health promoting effects of glucan

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glucan

Natural products, useful in preventing and treating various diseases, have been sought after for centuries. The investigation of glucans begun during the 1960s. Now, glucan represents the most thoroughly studied natural immunomodulator

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Cathepsin D

Cathepsin D and its enzymatically inactive precursor procathepsin D play an important role in development of several types of cancer, including breast, lung and prostate cancer. In addition to evaluation of these effects, our laboratory is actively seeking preparation of a dependable method for using procathepsin D and its antibodies as prognostic marker

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patents

Several international patents were based on experiments performed in our laboratory, both from funded research and from cooperation with international companies. Readers interested in use of any of the patent can contact us directly

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clinical trials papers

Vetvicka, V., Richter, J., Svozil, V., Rajnohova-Dobiasova, L., Kral, V.: Placebo-driven clinical trials of Transfer Point Glucan #300 in children with chronic respiratory problems: Antibody production. Am. J. Immunology 9 (2): 43-47, 2013

Vetvicka, V., Richter, J., Svozil, V., Rajnohova-Dobiasova, L., Kral, V.: Placebo-driven clinical trials of Transfer Point Glucan #300 in children with chronic respiratory problems: III. Clinical findings. Am. J. Immunol., 9:88-93, 2013.

Vetvicka, V., Richter, J., Svozil, V., Rajnohova-Dobiasova, L., Kral, V.: Placebo-driven clinical trials of yeast-derived B-(1,3) glucan in children with chronic respiratory problems. Ann. Transl. Med 1 (3): 26, 2013

Richter, J., Svozil, V., Rajnohova-Dobiasova, L., Stiborova, I., Kral, V., Vetvicka V: Clinical trials of yeast-derived B-(1,3) glucan in children: effects on innate immunity. Ann. Transl. Med. 2(2), 2014

Vetvicka, V., Richter, J., Svozil, V., Rajnohova-Dobiasova, L., Kral, V., Pohoroska J, Stiborova I: Effects of Trasnsfer Point Glucan #300 Supplementation on children exposed to Passive smoking - Placebo driven Double-blnd clinical trials. Journal of Nutrion Health, 2014

Vetvicka, V., Richter, J., Kral, V., Rajnohova, L., Stiborova, I., Pohorska, J: Regulation of Hematopoiesis in Cancer Patients: Placebo-Driven, Double-Blind Clinical Trials of B-Glucan. Journal of Tumor 18, 2015

Richter J., Svozil, V., Kral, V., Rajnohova, L., Vetvicka V: B-glucan affects mucosal immunity in children with chronic respiratory problems under physical stress: clinical trials. Annal of Transl. Medicine, 3, 2015

Vetvicka V, et al: Effects of Transfer Point Glucan #300 supplementation on children exposed to passive smoking, 2014 PDF



glucan papers

Vetvicka, V., Vetvickova J.: Glucan-Resrevatrol-Vitamin C Combination Offers Protection against Toxic Agents. Toxins, 2012

Vetvicka V., Vetvickova J.: Combination of Glucan, Resveratrol and Vitamin C Demonstrates Strong Anti-tumor Potential. Anticancer Research, 2012

Vetvicka V., Vetvickova J.: B (1-3)-D-glucan affects adipogenesis, wound healing and inflammation. Orient. Pharm Exp Med, 2011

Vetvicka V., Vetvickova J.: B 1,3-Glucan: Silver Bullet or Hot Air? Open Glycoscience 3, 2010

Vetvicka, V. - Effects of Beta glucan on some environmental toxins, 2014..PDF

Vetvicka V., Natural Immunomodulators and their stimulation of immune reaction, 2014 PDF

Vetvicka V., Garcia-Mina JM., Proctor M., Yvin JC: Humic Acid and Glucan: Protection Against Liver Injury Induced by Carbon Tetrachloride. J of Medicinal Food, 18, 2015

cathepsin d papers

Vetvicka V, Cathepsin D: Autoantibody profiling as a diagnostic marker for cancers, 2013, PDF DOCUMENT

Aruna Vashishta, Vetvicka V.: Search for cancer treatment continues: Procathepsin D. World Journal of Pathology, 2012

Vetvicka V., Fusek M., Vashishta A.: Procathepsin D Involvement in Chemoresistance of Cancer Cells. North Am. J. of Med. Sciences, 2012 

Vetvicka V., Vetvickova J.: Procathepsin D and Cytokines Influence the Proliferation of Lung Cancer Cells. Anticancer Research 31, 2011

Benes P, Vetvicka V, Fusek M.: Cathepsin D-Many functions of one aspartic protease. Oncology Hematology 2008

Selicharova I, Sanda M, Mladkova J, Ohri SS, Vashishta A, Fusek M, Jiracek J, Vetvicka V.: 2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: Comparison with parental cell line MDA-MB-231.Oncology Reports 19, 2008

Ohri SS, Vashishta A, Proctor M, Fusek M, Vetvicka V.: The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells. Int J Oncology, 32, 2008

Ohri SS, Vashishta A, Proctor M, Fusek M, Vetvicka V.: Depletion of Procathepsin D Gene Expression by RNA Interference: A Potential Therapeutic Target for Breast Cancer. Cancer Biol. Therapy 6, 2007

Vashishta A, Ohri SS, Proctor M, Fusek M, Vetvicka V.: Ribozyme-targeting procathepsin D and its effect on invasion and growth of breast cancer cells: an implication in breast cancer therapy. Int. J. Oncology 30, 2007

Saraswat-Ohri S., Vashishta A., Fusek M., Vetvicka V., Vetvickova J.: Procathepsin D expression correlates with invasive and metastatic phenotype of MDA-MB-231 derived cell lines. International Journal of Biological Macromolecules, 41, 204 - 209, 2007

Aruna Vashishta, Sujata Saraswat Ohria, Jana Vetvickova, Martin Fusek, Jitka Ulrichova, Vaclav Vetvicka: Procathepsin D secreted by HaCaT keratinocyte cells–A novel regulator of keratinocyte growth. European Journal of Cell Biology 86, 303-313, 2007

Fusek M., Vetvicka V., Vetvickova J.: Secretion of Cytokines in Breast Cancer Cells: The Molecular mechanism of Procathepsin D Proliferative Effects. Journal of Interferon & Cytokine Research 27: 191-199, 2007 

Saraswat-Ohri S., Vashishta A., Fusek M., Vetvicka V., Vetvickova J.: Procathepsin D expression correlates with invasive and metastatic phenotype of MDA-MB-231 derived cell lines. International Journal of Biological Macromolecules, 41, 204 - 209, 2007

patents

Glucan 

  • Yvin, J.C., Vetvicka, V.: Therapeutical treatment, US Patent # 6,660,722
  • Yvin; J.C, Panak; E., Vetvicka; V.: Therapeutical combination against cancer US Patent # 7,070,778
  • Yvin; J.C, Panak; E., Vetvicka; V.: Therapeutical combination against cancer EU Patent # 200500925250
  • Yvin, J.C., Vetvicka, V.: Chemotherapeutic antineoplastic treatment, Patent Number: 7,671,040
  • Yvin, J.C., Vetvicka, V.: Chemotherapeutic antineoplastic treatment, EU Patent # 20050065111
  • Yvin, J.C., Jamois, F., Vetvicka, V.: Therapeutical treatment with oligo-beta-(1,3)-glucans, dryg used in said treatment. EU Patent # 20050065114
  • Vetvicka, V., Fusek, M.: Method for inhibition of breast tumor growth, US Patent # 5,800,814
  • Yvin, J.C. Descroix, K., Ferrieres, V., Jamois, F., Laurent, I., Vetvicka, V.: Oligo-beta-(1,3)-glucan-(1,3)-mannose, oligo-beta-(1,3)-glucane-(1,3)-mannitol and derivatives thereof for treating diseases of the immune system, methods for preparing the same and drugs containing them. EU Patent # EP 2102222
  • Yvin, J.C., Panak, E., Vetvicka, V.: Oligo-beta-(1,3)-glucan and monoclonal antibodies against cancer. EU Patent # EP1684770
  • Yvin, J.C., Jamois, F., Vetvicka, V.: Pharmaceutical composition and therapeutic treatment with oligo-beta-(1,3)-glucans. EU Patent EP1663258
  • Yvin, J.C. Descroix, K., Ferrieres, V., Jamois, F., Laurent, I., Vetvicka, V.: Use of modified oligo-beta-(1,3)-glucans for treating diseases of the immune system, oligo-beta-(1,3)-glucan-(1,3)-mannose, oligo-beta-(1,3)-glucan-mannitol and derivates thereof, methods for preparing them and medicaments containing them. US Patent # 8,367,641
  • Yvin, J.C., Vetvicka, V.: Use of laminarin in the treatment of cancer. EU Patent # EP1448215
Cathepsin D